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KMID : 0379519880040010037
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한국독성학회지
1988 Volume.4 No. 1 p.37 ~ p.45
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Cytotoxicity of T-2 Toxin on Primary Cultures of Rat Hepatocytes
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Kim Hwan-Mook
Kim Byung-Sam
Choe Suck-Young
Yang Kyu-Hwan
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Abstract
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Primary cultures of adult rat hepatocytes were used to study in vitro cytotoxic effects of T-2 toxin on liver cells. When T-2 toxin was added to the culture, a significant depression of the hormonal induction of {alpha}-aminoisobutyric acid (AIB) uptake and tyrosine aminotransferase (TAT) activity was observed. However, T-2 toxin did not affect the uptake of ouabain into hepatocytes. Protein synthesis was inhibited by T-2 toxin, but RNA synthesis was not severely affected. The inhibitory effects of T-2 toxin on protein synthesis was diminished rapidly with culture time and the hepatocytes culture maintained control level of protein synthesis within 24 hrs.
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KEYWORD
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T-2 toxin, cytotoxicity, primary rat hepatocytes culture
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